Determining the 3d structure of a protein took yearsuntil very recently. Folding at Home was a worldwide project linking millions of computers to work on it.

Alphafold does it in under a second, and has revealed the structure of 200 million proteins. It’s one of the most significant medial achievements in history. Since it essentially dates back to 2022, we’re still a few years from feeling the direct impact, but it will be massive.

You realize that’s because the gigantic server farms powering all of this “AI” are orders of magnitude more powerful than the sum total of all of those idle home PC’s, right?

Folding@Home could likely also do in it in under a second if we threw 70+ TERAwatt hours of electricity at server farms full of specialzed hardware just for that purpose, too.

Original pre-microsoft Skype was not AS bloaty. It ran on my underpowered PC at the time with no issues.

Several patches/versions/whatever after Ms gutted the p2p aspect and centralized the servers, it slowed waaaaaay the hell down.

Make of that anecdotal evidence what you will.