Computational biochemistry is slowly getting there. Alphafold was a big breakthrough, and there is plenty of ongoing research simulating more and more.
We can probably never get rid of animal testing entirely for clinical research, we’ll always need to validate simulations in animals before moving on to humans.
I do however agree that animal testing outside of clinical research approved by a competent independent ethics committee can fuck right off. (Looking at you, cosmetics industry)
We can probably never get rid of animal testing entirely for clinical research, we’ll always need to validate simulations in animals before moving on to humans.
Getting rid of animal testing is the exact purpose of organ-on-a-chip research! This is actual bioengineered cultures, not simulations (not dissing on computational biochemistry - also extremely important)
If you can test without the full animal, then models (in this context, models = what you use for testing, be it cultures or animals) based on human induced pluropotent stem cells (ie cells taken from live, adult humans and forced to revert to a stem cell status) in an in vitro setting can actually be more relevant to human physiology than live animal models.
There are a lot of caveats (if it were easy, it would already be done), and there are barriers needed to be overcome for in vitro models to even come close to in vivo and ex vivo models. But a lot of people are investing in it, not (only) due to ethics but also due to lower model cost and better match of in vitro results with the actual effect on a live human body.
I can give papers when I get home, if you want.
Edit: I went on a deep dive on medical applications: suffice it to say, this is useless for behavioral experiments
Yeah. Fuck those scientists. Especially the ones that have created life saving things like penicilling, insuling. And its so shitty they used lab rats to test useless things like covid vaccines lately. I mean why to use poor rats. They could just have tested the vaccines with poor people.
And fuck cancer treatment too. Lets just treat people blindly, they are going to die anyway, why not make their last moments suffering just because you like mouses. Maybe we just should stop trying to cure cancer.
Fuck all animal testing and every scientist participating in it.
Computational biochemistry is slowly getting there. Alphafold was a big breakthrough, and there is plenty of ongoing research simulating more and more.
We can probably never get rid of animal testing entirely for clinical research, we’ll always need to validate simulations in animals before moving on to humans.
I do however agree that animal testing outside of clinical research approved by a competent independent ethics committee can fuck right off. (Looking at you, cosmetics industry)
Getting rid of animal testing is the exact purpose of organ-on-a-chip research! This is actual bioengineered cultures, not simulations (not dissing on computational biochemistry - also extremely important)
If you can test without the full animal, then models (in this context, models = what you use for testing, be it cultures or animals) based on human induced pluropotent stem cells (ie cells taken from live, adult humans and forced to revert to a stem cell status) in an in vitro setting can actually be more relevant to human physiology than live animal models.
There are a lot of caveats (if it were easy, it would already be done), and there are barriers needed to be overcome for in vitro models to even come close to in vivo and ex vivo models. But a lot of people are investing in it, not (only) due to ethics but also due to lower model cost and better match of in vitro results with the actual effect on a live human body.
I can give papers when I get home, if you want.
Edit: I went on a deep dive on medical applications: suffice it to say, this is useless for behavioral experiments
Yeah. Fuck those scientists. Especially the ones that have created life saving things like penicilling, insuling. And its so shitty they used lab rats to test useless things like covid vaccines lately. I mean why to use poor rats. They could just have tested the vaccines with poor people.
And fuck cancer treatment too. Lets just treat people blindly, they are going to die anyway, why not make their last moments suffering just because you like mouses. Maybe we just should stop trying to cure cancer.
What’s wrong with thalidomide? We can just put the shelves lower!